🍼 Nourish smarter, parent stronger — the formula that keeps you ahead.
Enfamil Optimum is a premium infant formula designed to closely mimic breast milk by including lactoferrin, a key immune protein, and a dual HMO blend to support immune health. Enhanced with brain-building DHA, it offers complete, non-GMO nutrition without artificial additives, ideal for infants up to 12 months. Trusted by pediatricians and parents alike, it provides convenient powder feeding with added benefits through the Enfamil Family Beginnings rewards program.








| ASIN | B01ASIEJPA |
| Best Sellers Rank | #1,202 in Baby ( See Top 100 in Baby ) #24 in Powder Baby Formula |
| Customer Reviews | 4.8 4.8 out of 5 stars (4,449) |
| Is Discontinued By Manufacturer | No |
| Item model number | 157401 |
| Manufacturer | Mead Johnson Nutrition |
| Manufacturer recommended age | 0 - 1 months |
| Product Dimensions | 4.4 x 6.3 x 5.5 inches; 1.28 Pounds |
| UPC | 300875117484 |
| Units | 20.5 Ounce |
K**N
Quest to find the right formula for 4m old twins
UPDATE (below ----- is my previous review) It's been almost a month since my previous review (4stars -1due to high price) and I wanted to come back for an update. I changed it to 5 stars because of an amazing story. Till now, the younger twin has been on 1/2 Gentlease and 1/2 Enspire VS The older twin 100% Enspire for about 5 weeks now. When I wrote the previous revie, the younger twin has already turned from back to his tummy (he was on 100%Gentlease and the older one had no intention of trying to turn (he was on Gerber Good Start Gentle+Similac Advanced). About 3 weeks into using Enspire, one day, the older twin managed to turn to the left and right and rolled over and over and over, all in one day and I have not been trying to teach him to do any of these! The younger twin, as of today, could roll but he still only turn from back to tummy from his left and he has trouble getting his arm out from his belly. I can't say if the get it all in one day miracle of the older twin was because he drank more Enspire than his younger brother, it probably can be just be a coincidence. But we were just so shocked by this and now we can't wait to finish the remaining 3 cans of Gentlease and have the younger twin on 100% Enspire. ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- I have twin boys born at 36 weeks, June 1, 2016, 5.5lb each. They are formula fed exclusively from birth. We started with Similac Advanced ready to feed (what the hospital gave us), one of the boys (Baby A) is fine with it but the other (Baby B) gets constipated and his tummy seem to be very uncomfortable after 2 weeks of use on Similac. Then I switched baby B to Enfamil Gentlease ready to feed, it worked like a miracle! After first feeding, he was happy and calm and he drank it quickly with pleasure! Baby A didn't like Gentlease at all so I kept him on Advanced. Later, I read some reviews on Amazon and some reviewers stated that Gentlease has corn starch solids which may be a bad ingredient for babies, so I tried Gerber Gentle Good Start ready to feed. Baby B occasionally drink Gerber but it was obvious he prefers the taste Gentlease a lot more, so I had to keep him on Gentlease. Baby A drank Gerber Gentle almost all the time, but he still prefers Similac Advanced (drinks faster on Similac). About a week ago, I learned about Enfamil Enspire and decided to give it a try! Baby A LOOOOOOVES it as much as he loves Similac Advanced. Baby B still prefers Gentlease but I have him on 1/2 Enspire and 1/2 Gentlease and he's fine with it. I don't mind the extra cost because I want the best for my babies, to make it up to them that I'm not able to breastfeed them at all. I don't know if Enspire is really better to worth the extra cost but their advertised statement "our closest to breast milk" is just too powerful. Yes, I'm a sucker for advertisement and other people's reviews. My babies have been on 1) Similac Advanced ready to feed (from birth at hospital) 2) Enfamil Gentlease ready to feed & powder (for baby B, easy to mix, not foamy if you shake the bottle to mix, excellent bowl movement, less spit up/vomiting) 3) Similac Neosure ready to feed for premature babies (2 bottles of 32oz ready to feed) - it made both of them constipated and uncomfortable. 4) Gerber Good Start Gentle ready to feed (somehow both of them don't like it, I think it's the taste) 5) Enfamil Enspire powder ( CAUTION: VERY FOAMY if you shake the bottle, I use a chopstick to stir it instead to avoid the foam of tiny bubbles) (EXCELLENT, REGULAR POOP, NO PROJECTILE VOMITING SINCE I started on this a week ago, BABY B had problem keeping in Similac and Gerber, he had projectile vomit about once to twice a week, which is not that bad , but still scary!) I know it's crazy that they have already tried all these different formulas, but they gained weight really well, they are both at 15lb. now! It's amazing! I have only started the Enspire a week ago so I don't know if it will continue to help them thrive at gaining weight. I will come back to update in a month or two. I'm determined at this point to have them both stay on this formula. (eventually changing 1/2 Gentlease 1/2 Enspire to Enspire exclusively if Baby B would respond well to it)
J**T
If you can afford it this is the winner.
Let me start by saying this formula is likely not the "best tasting" one out there. "Best tasting" when it comes to food is often the worst when it comes to nutrition. If you're concerned about taste/smell this formula is probably not for you. I personally am un-bothered by the smell and only read the nutritional label when making my choice. If you're concerned about the quality of ingredients, don't want an obese child, and want to give your kid the best nutritional formula the US has to offer.... This product is for you. Secondly, I highly recommend ordering the refill packs on Amazon. Get your initial plastic tub from the grocery store then refill it the $55 box from Amazon. It's cheaper and you don't have to worry about seals being broken. This stuff is expensive.... But it helped develop my thriving 10-month-old who is talking, laughing, smiling, communicating, and hitting all of her physical milestones with ease. She was born 5 weeks early and we worried about her mental development. She was tiny and behind other babies at first in her milestones. Since my wife breastfed and could never keep up, this was initially recommended by our pediatrician to help supplement and eventually transition from breast milk. The lactoferrin and MFGM are the special ingredients along with lactose being it's only sweetener instead of corn syrup. The MFGM makes a big difference in mental development while the lactoferrin helps develop a healthy gut (which attributes to the loads of parents saying this is the only thing their little ones can keep down). These are the only two ingredients that set it apart from traditional formulas... and they truly make a world of difference. This stuff is great. If it is just a little too expensive check out Enfamil NeuroPro... Which is basically the same thing just minus the Lactoferrin (it still contains the brain developing MFGM). Hopefully next time our next child decides to stay in the belly full-term, the breastfeeding starts off on the right foot and continues through one year. If not, I won't think twice before using Enfamil Enspire again. It's truly a no-brainer and we are so grateful to Enfamil for developing this incredible formula.
L**M
Great formula — gentle on baby’s tummy and mixes well
We’ve been using Enfamil Optimum for our baby and it’s been working really well. No issues with gas, spit-up, or tummy discomfort — which was a huge relief finding our go to formula on the first try. It mixes smoothly (no weird clumps), and our baby took to the taste without any fuss. It also seems to keep them full and content between feedings. Honestly, it’s just been a great fit for us. Peace of mind knowing baby is getting good nutrition and it agrees with their system. Definitely recommend trying it if you’re looking for a quality formula that’s easy on sensitive tummies.
R**E
Great Value. My Son Loves It
This is a great value and the best price I can find for Enfamil Optimum on the market. The quality is consistent. My son loves the taste. He has been enjoying it since borned. Very happy with this formula.
S**M
Closest to BM
Looking for formula that’s closest to breast milk? This is it!!! My LO has been on this since 5 months old. Never any issues loves it!!
C**N
Pricey but Great!
Both of my babies have thrived on this formula and done so well on it. We accidentally switched formulas from a Similac to this cold turkey on one of my babies (miscommunication with husband) and thankfully, he did just fine. No issues at all. Way more pricey than some formulas but I think its the worth the cost- especially if you wait for sales or use coupons.
Trustpilot
4 days ago
2 weeks ago