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🛡️ Keep your XL dog unstoppable with 30 days of triple-action pest defense!
Bayer K9 Advantix II offers six monthly topical treatments designed for extra-large dogs over 55 lbs. This EPA-approved formula kills 98-100% of fleas within 12 hours and provides continuous protection against fleas, ticks, and mosquitoes for 30 days per application. Water-resistant and veterinarian recommended, it prevents dangerous tick-borne diseases and repels pests on contact without requiring a bite.













| ASIN | B004QRJJ0K |
| Active Ingredients | Imidacloprid, Permethrin, Pyriproxyfen |
| Age Range Description | Senior |
| Allergen Information | Crab |
| Best Sellers Rank | #47,048 in Pet Supplies ( See Top 100 in Pet Supplies ) #57 in Dog Flea Drops |
| Brand Name | K9 Advantix |
| Customer Reviews | 4.6 4.6 out of 5 stars (16,282) |
| Global Trade Identification Number | 00724089204295 |
| Included Components | Tablets |
| Item Form | Topical |
| Item Type Name | Advantix |
| Item Weight | 45 g |
| Manufacturer | K9 Advantix |
| Manufacturer Part Number | 86315068 |
| Model Number | 81520429 |
| Scent Name | water |
| Target Species | Dog |
| UPC | 024089616501 724089204295 |
| Unit Count | 6 Count |
| Volume | 24 Milliliters |
Y**N
I brought my dog to West Virginia, and thank God for Advantix II — because I’ve been finding half-dead ticks every single day (no joke) in places where she sleeps or rests. At first, I was confused. I thought "repels ticks" meant it would work like bug spray does for mosquitoes, keeping them away completely. But after looking into the active ingredient, permethrin, I realized that in this case, “repel” means: once a tick touches the treated fur, it becomes so irritated or neurologically impaired that it can’t bite, can’t hang on, and eventually just falls off and dies. That’s still so much better than PetArmor, Frontline, or any of the oral preventatives (like Simparica or NexGard), which require the tick to bite the dog before it dies. No thanks. Every tick I’ve found so far had already dropped off my dog before it had a chance to bite her and feed — exactly what you want in a tick-heavy area. I’ve also tried Wondercide (cedar oil). It works okay for fleas, but it’s just not effective for ticks, especially not in the long term. Its protection wears off after 2–4 hours. I learned the hard way — my dog caught Lyme disease, developed joint pain and a limp. Thankfully, doxycycline helped and she’s okay now, but it required a full 28-day antibiotic course. I would never use oral flea/tick medications. Just ask around — you’ll hear plenty of stories about dogs having seizures after taking them. For me, that risk isn’t worth it. If you have a cat at home, unfortunately Advantix II may not be right for your household — permethrin is toxic to cats (especially when wet). But if you don’t have cats, I highly recommend this product to all dog owners. Tick-borne diseases are no joke. Fleas are annoying — I’ve had to go through the nightmare of clearing an infestation — but at least they just suck blood without causing life-threatening illness. Ticks, on the other hand, can transmit Lyme, Ehrlichia, Rocky Mountain spotted fever, and more. So if you live somewhere warm, humid, grassy, or deer-heavy — do your dog a favor and get Advantix II. It’s been a lifesaver for us.
L**N
Awesome! I have a German shepherd, he is unable to take the vets flea and tick meds due to vomiting ever time he take it. The vet prescribes this super expensive topical for fleas and ticks as we live out in farm fields and ticks are really common. I found that this is the exact same as the veterinary one for less than 1/2 the price. We have been using this for a year I have noticed no reactions or scratching. If he gets a tick it comes off really easily with tweezers. But I’m still going to take him to the vet once a year for his wellness check up or if I have any issues. Please take your animals to the vet first but this works great if you’re on a budget
J**E
Easy to apply have used this for years and works great. We live in a wooded area and I love not having to constantly do tick checks
R**E
Great
D**W
Item as described
Trustpilot
3 days ago
2 weeks ago